Out of Patients with Matthew Zachary
Out of Patients with Matthew Zachary
Matthew Zachary is the healthcare policy love child of Jon Stewart, Howard Stern, Thomas Paine, Ralph Nader, and Jerry Seinfeld. He has 19 years of receipts to prove it. Editorially independent. Answerable to no one. What started as The Stupid Cancer Show in 2007 became Out of Patients. The first online health podcast in America, predating the medium itself. Zachary survived brain cancer at 21, built the young adult cancer movement from scratch, and spent two decades channeling patient rage into something the system never saw coming. Now he is marching into Washington. Out of Patients goes where the comfortable shows will not. Politics. Healthcare policy. Economics. Institutional accountability. Consumer protection. The forces shaping what 330 million Americans can access, afford, and survive. Battle-scarred patients. Exhausted caregivers. Rare insiders brave enough to name what is killing us. And the occasional elected official about to find out what an organized patient constituency actually looks like. This is the show that started the conversation America is still not ready to finish.

Out of Patients with Matthew Zachary

Recent Episodes

8
Sept. 2, 2026

[HIATUS] The Cancer Mavericks EP8: The Inequity of Cure: Who Gets to Matter

In 1971, the National Cancer Act transformed cancer into a national research priority. More than 50 years later, the next frontier is no longer defined solely by scientific discovery, but by how quickly knowledge, lived experience, and patient voices can reshape healthcare itself. The concluding chapter of The Cancer Mavericks: A History of Survivorship explores how the cancer advocacy movement continues to evolve in an era of digital communities, social media, precision medicine, and grassroot
7
Aug. 31, 2026

[HIATUS] The Cancer Mavericks EP7: The Inequity of Cure: Who Gets to Matter

In 1987, Mary P. Lovato, a member of Kewa Pueblo in New Mexico, was diagnosed with acute leukemia. To receive a bone marrow transplant, she had to travel more than 800 miles from home because specialized cancer care was unavailable through the Indian Health Service. When she returned, she discovered another obstacle: many in her community feared cancer so deeply that they avoided speaking about it altogether. This episode examines how cancer survivorship exposed profound inequities in the Ameri
6
Aug. 26, 2026

[HIATUS] The Cancer Mavericks EP6: Lights, Camera… Colonoscopy: Cancer Mavericks Go to Hollywood

In 2000, Katie Couric underwent a live colonoscopy on national television following the death of her husband, Jay Monahan, from colorectal cancer at age 42. The broadcast demystified a procedure many Americans feared, led to an estimated 20% increase in colonoscopy screenings, and became one of the clearest examples of how public storytelling can change healthcare behavior. This episode examines how celebrities, journalists, filmmakers, and entertainers helped reshape the public conversation ab

Recent Blog Posts

July 28, 2026

Out of Patients EP4534: Your Benefits May Vary: Rebecca Bloom

🚨NEW EPISODE 🚨 Rebecca Bloom spent years inside one of the least sexy but most consequential corners of American healthcare. Employee benefits law. Executive compensation. HR policy. The part of the machine where cancer quietly turns into paperwork…
July 22, 2026

Out of Patients EP453: Mission, Margin, and the Women Left Waiting with Vasanta Pundrika

WOMEN MAKE 80% OF HEALTHCARE SPENDING DECISIONS. THEY ALSO SPEND 25% MORE OF THEIR LIVES IN POORER HEALTH. THE SYSTEM FINALLY NOTICED THEY HAVE WALLETS. 🚨NEW EPISODE ALERT 🚨 Vasanta spent 20 years in healthcare investment banking before walking aw…
July 15, 2026

Out of Patients EP452:You Shouldn’t Need AI to Survive Cancer: Brad Power

Brad Power spent years helping corporations understand systems, incentives, and operational failure points before cancer forced him to study a very different machine. Now he runs Cancer Patient Lab and Open Cancer AI, which sounds futuristic until y…

About the Host

Matthew Zachary Profile Photo
Matthew Zachary

Producer

Matthew Zachary invented healthcare podcasting before podcasting was a thing. In 2007, fresh off building Stupid Cancer, he grabbed a mic, launched The Stupid Cancer Show, and started broadcasting patient stories on internet talk radio when everyone else was still writing blogs.

19 years and 2000+ episodes later, Out of Patients is still the most unfiltered healthcare show anywhere.

Matthew does not do softball interviews. Brain cancer at 21 taught him that time is finite and bullshit is expensive. He gets guests to say things they would never tell Congress. CEOs admit what is broken. Patients name what actually hurts. Scientists explain what industry does not want you to know. The conversations other shows will not touch because of sponsor concerns or political correctness.

What makes him different: he has been on both sides of the mic. Featured in documentaries. Keynoted hundreds of conferences. Published in The Hill. Now marching into Washington with a national patient constituency behind him.

But he has also been the guy puking from radiation, fighting insurance denials, and watching friends die from paperwork.

That dual perspective creates interviews you will not hear anywhere else. He knows which questions make power squirm because he has asked them from hospital beds and boardrooms both.

No pre-approved questions. No PR handlers. No seven-minute segments. Just real conversations with people brave enough to tell the truth about American healthcare.

Still the show where whistleblowers go first. Still the show Mark Cuban reposts when he wants to understand what patients actually think. Still asking the questions that make everyone uncomfortable.

Because comfortable conversations do not fix broken systems.

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